Understanding perirhinal contributions to perception and memory: Evidence through the lens of selective perirhinal damage

NEUROPSYCHOLOGIA

卷:124

Article

Inhoff, Marika C.¹  Heusser, Andrew C.²  Tambini, Arielle^3,4  Martin, Chris B.⁵  O'Neil, Edward B.⁶  Kohler, Stefan^7,8  Meager, Michael R.^9,15  Blackmon, Karen^9,12  Vazquez, Blanca⁹  Devinsky, Orrin^9,10,11  Davachi, Lila^13,14 

[1] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

[2] Dartmouth Coll, Dept Psychol & Brain Sci, Hanover, NH 03755 USA

[3] Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[5] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[6] Univ Toronto Scarborough, Dept Psychol, Toronto, ON, Canada

[7] Western Univ, Brain & Mind Inst, London, ON, Canada

[8] Western Univ, Dept Psychol, London, ON, Canada

[9] NYU, Sch Med, Dept Neurol, Langone Med Ctr, New York, NY USA

[10] NYU, Sch Med, Dept Neurosurg, New York, NY USA

[11] NYU, Sch Med, Dept Psychiat, New York, NY USA

[12] St Georges Univ, Sch Med, Dept Physiol Neurosci & Behav Sci, St Georges, Grenada

[13] Columbia Univ, Dept Psychol, New York, NY 10027 USA

[14] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA

[15] NYU, Dept Psychol, 6 Washington Pl, New York, NY 10003 USA

关键词: Perirhinal cortex;    Memory;    Perception;    Hippocampus;    Medial temporal lobe;   

DOI  :  10.1016/j.neuropsychologia.2018.12.020

来源: Elsevier

【 摘 要 】

Although a memory systems view of the medial temporal lobe (MU) has been widely influential in understanding how memory processes are implemented, a large body of work across humans and animals has converged on the idea that the MTL can support various other decisions, beyond those involving memory. Specifically, recent work suggests that perception of and memory for visual representations may interact in order to support ongoing cognition. However, given considerations involving lesion profiles in neuropsychological investigations and the correlational nature of fMRI, the precise nature of representations supported by the MTL are not well understood in humans. In the present investigation, three patients with highly specific lesions to MTL were administered a task that taxed perceptual and mnemonic judgments with highly similar face stimuli. A striking double dissociation was observed such that I.R., a patient with a cyst localized to right posterior PRc, displayed a significant impairment in perceptual discriminations, whereas patient A.N., an individual with a lesion in right posterior parahippocampal cortex and the tail of the right hippocampus, and S.D., an individual with bilateral hippocampal damage, did not display impaired performance on the perceptual task. A.N. and S.D. did, however, show impairments in memory performance, whereas patient I.R. did not. These results causally implicate right PRc in successful perceptual oddity judgments, however they suggest that representations supported by PRc are not necessary for correct mnemonic judgments, even in situations of high featural overlap.

【 授权许可】

Free