Malignancy in Guillain-Barre syndrome: A twelve-year single-center study

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:375

Article

Hiew, Fu Liong¹  Rajabally, Yusuf A.^1,2 

[1] Univ Hosp Birmingham, Queen Elizabeth Hosp, Reg Neuromuscular Clin, Birmingham, W Midlands, England

[2] Aston Univ, Aston Brain Ctr, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England

关键词: Axonal;    Cancer;    Guillain-Barre syndrome;    Hyponatremia;    Malignancy;    Paraneoplastic;   

DOI  :  10.1016/j.jns.2017.02.024

来源: Elsevier

【 摘 要 】

The relationship between Guillain-Barre syndrome (GBS) and malignancy is uncertain. We retrospectively analyzed data of 118 consecutive patients admitted with GBS from Birmingham, U.K. (2001 2012). We calculated relative cancer risk using different definitions and determined characteristics of malignancy-associated GBS. Malignancy was globally commoner in our GBS cohort compared to the general population (odds ratio: 2.08; CI: 1.06-3.71; p = 0.036). However, this was unconfirmed if paraneoplastic criteria were applied. GBS patients with cancer were significantly more likely to be older (p = 0.043), hyponatremic (p = 0.037) and demonstrate more axonal loss (p < 0.05). Cerebrospinal fluid (CSF) protein levels were lower in the malignancy group (p = 0.002) and neurological improvement less likely (p = 0.023). In-patient mortality was significantly higher in patients with malignancy (p < 0.01). We conclude global cancer risk is higher in GBS than in the general population, although definition-dependent. Malignancy requires consideration in elderly, hyponatremic subjects with normal CSF protein, severe axonal loss, who fail to improve post-treatment. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

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