Impact of tetrabenazine on gait and functional mobility in individuals with Huntington's disease

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:347

Article

Kegelmeyer, Deb A.^1,4  Kloos, Anne D.^1,4  Fritz, Nora E.²  Fiumedora, Marianne M.¹  White, Susan E.³  Kostyk, Sandra K.^1,4 

[1] Ohio State Univ, Div Phys Therapy, Sch Hlth & Rehabil Sci, Columbus, OH 43210 USA

[2] Johns Hopkins Univ, Baltimore, MD 21218 USA

[3] Ohio State Univ, Div Hlth Informat, Sch Hlth & Rehabil Sci, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Neurol, Movement Disorders Div, Coll Med, Columbus, OH 43210 USA

关键词: Gait;    Function;    Mobility;    Huntington's disease;    Chorea;    Balance;   

DOI  :  10.1016/j.jns.2014.09.053

来源: Elsevier

【 摘 要 】

Chorea may contribute to balance problems and walking difficulties that lead to higher fall rates in individuals with Huntington's disease (HD). Few studies have examined the effects of tetrabenazine (TBZ), an anti-choreic drug, on function and mobility in HD. The purpose of this study was to compare: 1) gait measures in forward walking, 2) balance and mobility measures, and 3) hand and forearm function measures on and off TBZ. We hypothesized that use of TBZ would improve gait, transfers and hand and forearm function. Eleven individuals with HD on stable doses of TBZ were evaluated while off medication and again following resumption of medication. Significant improvements were found on the Unified Huntington's Disease Rating Scale (UHDRS) motor scores, Tinetti Mobility Test (TMT) total (t = 4.20, p = 0.002) and balance subscale (t = -4.61, p = 0.001) scores, and the Five Times Sit-to-Stand test (5TSST, t = 3.20, p = .009) when on-TBZ compared to off-TBZ. Spatiotemporal gait measures, the Six Condition Romberg test, and UHDRS hand and forearm function items were not changed by TBZ use. Improved TMT and 5TSST performance when on drug indicates that TBZ use may improve balance and functional mobility in individuals with HD. (C) 2014 The Authors. Published by Elsevier B.V.

【 授权许可】

Free