Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:333

Article

Yarchoan, Mark¹  Louneva, Natalia²  Xie, Sharon X.³  Swenson, Frank J.⁴  Hu, William⁵  Soares, Holly⁶  Trojanowski, John Q.⁷  Lee, Virginia M. -Y.⁷  Kling, Mitchel A.⁸  Shaw, Leslie M.⁹  Chen-Plotkin, Alice¹⁰  Wolk, David A.¹⁰  Arnold, Steven E.^2,10 

[1] Univ Penn, Dept Internal Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[4] Pfizer Diagnost, PharmaTX Precis Med, Groton, CT USA

[5] Emory Univ, Emory Alzheimers Dis Res Ctr, Atlanta, GA 30322 USA

[6] Pfizer Global Res & Dev, Groton, CT USA

[7] Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[8] Philadelphia VA Med Ctr, Behav Hlth Serv, Philadelphia, PA USA

[9] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA

[10] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

关键词: Alzheimer disease;    Mild cognitive impairment;    C-reactive protein;    Inflammation;    Biological markers;    Apolipoprotein E;   

DOI  :  10.1016/j.jns.2013.05.028

来源: Elsevier

【 摘 要 】

C-reactive protein (CRP) participates in the systemic response to inflammation. Previous studies report inconsistent findings regarding the relationship between plasma CRP and Alzheimer's disease (AD). We measured plasma CRP in 203 subjects with AD, 58 subjects with mild cognitive impairment (MCI) and 117 normal aging subjects and administered annual Mini-Mental State Examinations (MMSE) during a 3-year follow-up period to investigate CRP's relationship with diagnosis and progression of cognitive decline. Adjusted for age, sex, and education, subjects with AD had significantly lower levels of plasma CRP than subjects with MCI and normal aging. However, there was no significant association between plasma CRP at baseline and subsequent cognitive decline as assessed by longitudinal changes in MMSE score. Our results support previous reports of reduced levels of plasma CRP in AD and indicate its potential utility as a biomarker for the diagnosis of AD. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

Free