Rest tremor in Parkinson's disease: Body distribution and time of appearance

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:375

Article

Gigante, Angelo Fabio¹  Pellicciari, Roberta^1,2  Iliceto, Giovanni¹  Liuzzi, Daniele¹  Mancino, Paola Vincenza¹  Custodero, Giacomo Emanuele¹  Guido, Marco¹  Livrea, Paolo¹  Defazio, Giovanni¹ 

[1] Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sensory Organs, Bari, Italy

[2] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

关键词: Parkinson's disease;    Rest tremor;    Body distribution;    Time of appearance;    Upper limb;    Lower limb;   

DOI  :  10.1016/j.jns.2016.12.057

来源: Elsevier

【 摘 要 】

Objective: To assess body distribution and timing of appearance of rest tremor in Parkinson's disease. Methods: Information was obtained by a computerized database containing historical information collected at the first visit and data collected during the subsequent follow-up visits. Information on rest tremor developed during the follow-up could be therefore obtained by our own observation in a proportion of patients. Results: Among 289 patients, rest tremor was reported at disease onset in 65.4% of cases and detected at last follow-up examination in 74.4% of patients. Analysis of patients who did not report rest tremor at disease onset indicated that 26% of such patients (9% in the overall population) manifested rest tremor over the disease course. Rest tremor spread to new sites in 39% of patients who manifested rest tremor at disease onset. Regardless of tremor presentation at disease onset or during the follow-up, upper limb was the most frequent tremor localization. Over the follow-up, rest tremor developed faster in the upper limb than in other body sites. The risk of developing rest tremor during the follow-up was not affected by sex, side of motor symptom onset and site of tremor presentation. However, age of disease onset >63 years was associated with an increased risk of rest tremor spread. Conclusions: This study provides new information about body distribution and timing of rest tremor appearance during the course of early stages of Parkinson's disease that may help clinicians in patients' counselling. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free