Multisequence-imaging protocols to detect cortical lesions of patients with multiple sclerosis: Observations from a post-mortem 3 Tesla imaging study

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:282

Article

Bagnato, Francesca¹  Yao, Bing²  Cantor, Fredric¹  Merkle, Hellmut²  Condon, Ellen³  Montequin, Marcela³  Moore, Sandra³  Quezado, Martha⁴  Tkaczyk, Deborah³  McFarland, Henry¹ 

[1] NINDS, Neuroimmunol Branch NIB, NIH, Bethesda, MD 20892 USA

[2] NINDS, Adv MRI Sect, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA

[3] NIMH, NIH, Bethesda, MD 20892 USA

[4] NCI, Pathol Lab, Surg Pathol Sect, NIH, Bethesda, MD 20892 USA

关键词: Multiple sclerosis;    Post-mortem imaging;    3-Tesla MRI;    Cortical lesions;    Neurodegeneration;    Inflammation;   

DOI  :  10.1016/j.jns.2009.03.021

来源: Elsevier

【 摘 要 】

Neocortical lesions (NLs) are an important component of multiple sclerosis (MS) pathology and may account for part of the physical and cognitive disability. Visualizing NLs of patients with MS using magnetic resonance imaging (MRI) poses several significant challenges. We optimized the inversion time (TI) of T(1)-based magnetization-prepared rapid acquisition gradient-echo (MPRAGE) images by suppressing the signal of the lesions and enhancing their appearance as hypo intensities, on the basis of the derived quantitative T(1) measurements. The latter were achieved by the means of 2D inversion recovery fast spin echo (IR-FSE), repeated using different inversion times (TI). Comparisons of detection of NLs by MPRAGE and dual echo T(2) weighted (T(2)W) and proton density (PD) W. Four coronal brain slices from a deceased MS patient and two coronal brain slices from two formerly healthy donors were imaged using a 3 Tesla magnet (3 T) equipped with a multi-channel coil. Based upon the averaged T1 values computed from the MS specimen as well as visual inspection, an optimal TI of 380 ms was selected for the MPRAGE image. No NLs were seen in the specimens of the two healthy donors. Of the 40 total NLs observed, 8 (20%) were visible in all three sequences employed. Three (7.5%) NLs were visible only in the PDW image and 5 (12.5%) were seen only in the T(2)W image. Four NLs (10%) had clearly unique conspicuity in the MPRAGE image. Of those, 3 were retrospectively scored in the PDW image (1 NL) or in the T2W image (2 NLs). We conclude that for the detection of MS-related NLs, high-resolution T(1)-based MPRAGE and T(2)-W images offer complementary information and the combination of the two image sequences is crucial for increasing the sensitivity of detecting MS-induced NLs. Published by Elsevier B.V.

【 授权许可】

Free