Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:315

Article

Moodie, Jennifer²  Healy, Brian C.¹  Buckle, Guy J.¹  Gauthier, Susan A.³  Glanz, Bonnie I.¹  Arora, Ashish¹  Ceccarelli, Antonia¹  Tauhid, Shahamat¹  Han, Xue-Mei¹  Venkataraman, Arun¹  Chitnis, Tanuja¹  Khoury, Samia J.¹  Guttmann, Charles R. G.⁴  Weiner, Howard L.¹  Neema, Mohit¹  Bakshi, Rohit¹ 

[1] Harvard Univ, Brigham & Womens Hosp, Lab Neuroimaging Res, Sch Med,Partners MS Ctr,Dept Neurol, Brookline, MA 02445 USA

[2] Univ Massachusetts, Dept Neurol, Boston, MA 02125 USA

[3] Weill Cornell Med Coll, Judith Jaffe Multiple Sclerosis Ctr, New York, NY USA

[4] Harvard Univ, Brigham & Womens Hosp, Dept Radiol, Sch Med, Brookline, MA 02445 USA

关键词: MRI;    Multiple sclerosis;    Neurologic disability;    T1 hypointense lesions;    T2 hyperintense lesions;    Brain atrophy;    Measurement scales;   

DOI  :  10.1016/j.jns.2011.11.040

来源: Elsevier

【 摘 要 】

Background: We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS). Objective: Test strength of the MRDSS vs. individual MRI measures for sensitivity to longitudinal change. Methods: We studied 84 MS patients over a 3.2 +/- 0.3 year follow-up. Baseline and follow-up T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF) were measured. MRDSS was the combination of standardized T2LV, T1/T2 ratio and BPF. Results: Patients had higher MRDSS at follow-up vs. baseline (p<0.001). BPF decreased (p<0.001), T1/T2 increased (p<0.001), and T2LV was unchanged (p>0.5). Change in MRDSS was larger than the change in MRI sub-components. While MRDSS showed significant change in relapsing-remitting (RR) (p<0.001) and secondary progressive (SP) phenotypes (p<0.05), BPF and T1/T2 ratio changed only in RRMS (p<0.001). Longitudinal change in MRDSS was significantly different between RRMS and SPMS (p=0.0027); however, change in the individual MRI components did not differ. Evaluation with respect to predicting on-study clinical worsening as measured by EDSS revealed a significant association only for T2LV (p=0.038). Conclusion: Results suggest improved sensitivity of MRDSS to longitudinal change vs. individual MRI measures. MRDSS has particularly high sensitivity in RRMS. (c) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free