General Health Status and Incidence of First-Onset Temporomandibular Disorder: The OPPERA Prospective Cohort Study

JOURNAL OF PAIN

卷:14

Article

Sanders, Anne E.^1,2  Slade, Gary D.^1,2,3  Bair, Eric^1,4,5  Fillingim, Roger B.^7,8  Knott, Charles⁹  Dubner, Ronald^10,11,12  Greenspan, Joel D.^10,11,12  Maixner, William^1,6  Ohrbach, Richard¹³ 

[1] Univ N Carolina, Reg Ctr Neurosensory Disorders, Chapel Hill, NC USA

[2] Univ N Carolina, Dept Dent Ecol, Chapel Hill, NC USA

[3] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[4] Univ N Carolina, Dept Endodont, Chapel Hill, NC USA

[5] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA

[6] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC USA

[7] Univ Florida, Coll Dent, Dept Community Dent & Behav Sci, Gainesville, FL USA

[8] Pain Res & Intervent Ctr Excellence, Gainesville, FL USA

[9] Battelle Mem Inst, Ctr Analyt & Publ Hlth, Durham, NC USA

[10] Univ Maryland, Sch Dent, Dept Oral & Maxillofacial Surg, Baltimore, MD 21201 USA

[11] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA

[12] Univ Maryland, Sch Dent, Brotman Facial Pain Ctr, Baltimore, MD 21201 USA

[13] SUNY Buffalo, Dept Oral Diagnost Sci, Buffalo, NY USA

关键词: Temporomandibular disorder;    prospective cohort studies;    comorbidity;    epidemiology;   

DOI  :  10.1016/j.jpain.2013.06.001

来源: Elsevier

【 摘 要 】

Temporomandibular disorder (TMD) overlaps with other health conditions, but no study has examined which of these conditions increase the risk of developing first-onset TMD. The authors prospectively evaluated the relationship between health status at enrollment and subsequent incidence of TMD in 2,722 men and women. Participants aged 18 to 44 years had no history of TMD and were clinically free of TMD when enrolled in 2006 to 2008 at 4 U.S. study sites in the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) prospective cohort study. First-onset examiner-classified TMD developed in 260 people over a median 2.8 years of follow-up. Cox regression estimated the association between health conditions and TMD incidence while accounting for potential confounders. Incidence of first-onset TMD was 50% higher for people with low back pain (adjusted hazard ratio [AHR] = 1.50,95% confidence limits [CLs]: 1.08, 2.10) and 75% higher for people with genital pain symptoms (AHR = 1.75, 95% CLs = 1.04, 2.93) than people without a history of these pain disorders. Digit ratio, a marker of intrauterine exposure to sex hormones, was significantly associated with TMD incidence. Other independent predictors of first-onset TMD were sleep disturbance and cigarette smoking. These findings reveal multiple influences of health status on incidence of first-onset TMD. (C) 2013 by the American Pain Society

【 授权许可】

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