An Overview of Animal Models of Pain: Disease Models and Outcome Measures

JOURNAL OF PAIN

卷:14

Review

Gregory, Nicholas S.^1,2  Harris, Amber L.⁴  Robinson, Caleb R.³  Dougherty, Patrick M.³  Fuchs, Perry N.^4,5  Sluka, Kathleen A.^1,2 

[1] Univ Iowa, Coll Med, Dept Phys Therapy & Rehabil Sci, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Med, Grad Program Neurosci, Iowa City, IA 52242 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Anesthesia & Pain Med Res, Houston, TX 77030 USA

[4] Univ Texas Arlington, Dept Psychol, Coll Sci, Arlington, TX 76019 USA

[5] Univ Texas Arlington, Dept Biol, Coll Sci, Arlington, TX 76019 USA

关键词: Pain;    animal model;    inflammation;    neuropathic;    cancer;    incision;    behavior;    reflex;    affective;    muscle;    joint;    place preference;    escape-avoidance;   

DOI  :  10.1016/j.jpain.2013.06.008

来源: Elsevier

【 摘 要 】

Pain is ultimately a perceptual phenomenon. It is built from information gathered by specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and integrated into a discrete sensory experience with an emotional valence in the brain. Because of this, studying intact animals allows the multidimensional nature of pain to be examined. A number of animal models have been developed, reflecting observations that pain phenotypes are mediated by distinct mechanisms. Animal models of pain are designed to mimic distinct clinical diseases to better evaluate underlying mechanisms and potential treatments. Outcome measures are designed to measure multiple parts of the pain experience, including reflexive hyperalgesia measures, sensory and affective dimensions of pain, and impact of pain on function and quality of life. In this review, we discuss the common methods used for inducing each of the pain phenotypes related to clinical pain syndromes as well as the main behavioral tests for assessing pain in each model. Perspective: Understanding animal models and outcome measures in animals will assist in translating data from basic science to the clinic. (C) 2013 by the American Pain Society

【 授权许可】

Free