Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:25

Article

Asquith, Christopher R. M.¹  Meli, Marina L.^2,3  Konstantinova, Lidia S.⁴  Laitinen, Tuomo⁵  Poso, Antti⁵  Rakitin, Oleg A.⁴  Hofmann-Lehmann, Regina^2,3  Allenspach, Karin⁶  Hilton, Stephen T.¹ 

[1] UCL, UCL Sch Pharm, Fac Life Sci, London WC1N 1AX, England

[2] Univ Zurich, Vetsuisse Fac, Clin Lab, CH-8057 Zurich, Switzerland

[3] Univ Zurich, Vetsuisse Fac, Ctr Clin Studies, CH-8057 Zurich, Switzerland

[4] Russian Acad Sci, Zelinsky Inst Organ Chem, Moscow 119991, Russia

[5] Univ Eastern Finland, Sch Pharm, Fac Hlth Sci, Kuopio 70211, Finland

[6] Univ London Royal Vet Coll, Vet Clin Sci, Hatfield AL9 7TA, Herts, England

关键词: FIV;    HIV;    Tetrathiocenes;    Nucleocapsid;    Zinc finger;   

DOI  :  10.1016/j.bmcl.2014.12.047

来源: Elsevier

【 摘 要 】

A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free