The Inside Out of Lentiviral Vectors

Viruses

Stéphanie Durand¹ 

[1] ¹Department of Human Virology, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France ²INSERM U758, 46 Allée d’Italie, 69364 Lyon, France ³University of Lyon 1, 50 Avenue Tony Garnier, 69364 Lyon, France ⁴IFR128 BioSciences Lyon-Gerland, Lyon-Biopole, 69364 Lyon, France

关键词: lentivirus;    lentiviral vector;    gene therapy;    HIV;    SIV;    EIAV;    FIV;   

DOI  :  10.3390/v3020132

来源: mdpi

【 摘 要 】

Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.