Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:23

Article

Mandadapu, Sivakoteswara Rao¹  Gunnam, Mallikarjuna Reddy¹  Kankanamalage, Anushka C. Galasiti¹  Uy, Roxanne Adeline Z.¹  Alliston, Kevin R.¹  Lushington, Gerald H.²  Kim, Yunjeong³  Chang, Kyeong-Ok³  Groutas, William C.¹ 

[1] Wichita State Univ, Dept Chem, Wichita, KS 67260 USA

[2] LiS Consulting, Lawrence, KS 66046 USA

[3] Kansas State Univ, Coll Vet Med, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA

关键词: alpha-Hydroxyphosphonates;    Transition state mimics;    Norovirus 3CL protease;    Inhibitors;   

DOI  :  10.1016/j.bmcl.2013.08.073

来源: Elsevier

【 摘 要 】

The design, synthesis, and evaluation of a series of dipeptidyl alpha-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity. (C) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

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