Synthesis of 3-diethylphosphonoyl-2-hydroxy-prop-2-ylphosphonate and -phosphine oxide derivatives via the Pudovik reaction of diethyl 2-oxopropylphosphonate on the surface of Al2O3/KF

TETRAHEDRON LETTERS

卷:68

Article

Varga, Petra R.¹  Haegele, Gerhard²  Keglevich, Gyoergy¹ 

[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary

[2] Heinrich Heine Univ Dusseldorf, Inst Inorgan Chem & Struct Chem, D-40225 Dusseldorf, Germany

关键词: Pudovik reaction;    alpha-Hydroxyphosphonates;    Solid phase synthesis;    P-31 NMR features;   

DOI  :  10.1016/j.tetlet.2021.152902

来源: Elsevier

【 摘 要 】

A series of dialkyl 3-diethylphosphonoyl-2-hydroxy-prop-2-ylphosphonates and a diphenylphosphine oxide, new representatives within the large family of alpha-hydroxyphosphonates, were prepared via the Pudovik reaction of the corresponding dialkyl phosphites or diphenylphosphine oxide with diethyl 2-oxopropylphosphonate on the surface of Al2O3/KF. The conformation of the alpha-hydroxy-ethylenebisphosphonate derivatives was established on the basis of stereospecific (3)J(PC) constants. (C) 2021 The Authors. Published by Elsevier Ltd.

【 授权许可】

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