Anticancer platinum(II) complexes bearing N-heterocycle rings

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:29

Review

Facchetti, Giorgio¹  Rimoldi, Isabella¹ 

[1] Univ Milan, Dept Pharmaceut Sci, Via Golgi 19, I-20133 Milan, Italy

关键词: Platinum(II) complex;    Monofunctional complex;    Bifunctional complex;    Tumor cell lines;    Cancer therapy;   

DOI  :  10.1016/j.bmcl.2019.03.045

来源: Elsevier

【 摘 要 】

Starting from the pioneering discovery of picoplatin and phenanthriplatin, many efforts were realized by different research groups in the synthesis of different platinum(II) complexes, bearing a N-heterocycle moiety active as anticancer agents in different types of solid tumors. This review deals in particular with both the bifunctional and monofunctional platinum drugs, not only in dichloride platinum(II) complexes, but also in recent advances in modern platinum structures, i.e. cationic ones. Both the in vitro and in vivo studies of these anticancer agents are taken into account, with a special consideration for aggressive and orphan in treatment tumors.

【 授权许可】

Free