Novel synthetic ligands for targeted PET imaging and radiotherapy of copper

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:17

Article

Chong, Hyun-Soon ; Mhaske, Santosh ; Lin, Mai ; Bhuniya, Sankar ; Song, Hyun A. ; Brechbiel, Martin W. ; Sun, Xiankai

关键词: synthetic chelates;    macrocyclic ligands;    Cu-64;    PET imaging;    targeted radiotherapy;    serum stability;   

DOI  :  10.1016/j.bmcl.2007.09.052

来源: Elsevier

【 摘 要 】

Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with Cu-64, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with Cu-64. (C) 2007 Elsevier Ltd. All rights reserved.

【 授权许可】

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