Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:25

Article

Penthala, Narsimha Reddy¹  Thakkar, Shraddha¹  Crooks, Peter A.¹ 

[1] Univ Arkansas Med Sci, Dept Pharmaceut Sci, Coll Pharm, Little Rock, AR 72205 USA

关键词: Heterocyclic resveratrol analogs;    Anti-cancer activity;    Indole;    Benzofuran;    Benzothiophene;    Benzothiazole;   

DOI  :  10.1016/j.bmcl.2015.05.019

来源: Elsevier

【 摘 要 】

Heteroaromatic analogs of DMU-212 (8-15) have been synthesized and evaluated for their anti-cancer activity against a panel of 60 human cancer cell lines. These novel analogs contain a trans-3,4,5-trimethoxystyryl moiety attached to the C2 position of indole, benzofuran, benzothiazole or benzothiophene ring (8, 11, 13 and 14, respectively) and showed potent growth inhibition in 85% of the cancer cell lines examined, with GI(50) values <1 mu M. Interestingly, trans-3,4-and trans-3,5-dimethoxystyryl DMU-212 analogs 9, 10, 12 and 15 exhibited significantly less growth inhibition than their 3,4,5-trimethoxystyryl counterparts, suggesting that the trans-3,4,5-trimethoxystyryl moiety is an essential structural element for the potent anti-cancer activity of these heterocyclic DMU-212 analogs. Molecular modeling studies showed that the four most active compounds (8, 11, 13 and 14) all bind to the colchicine binding site on tubulin, and that their binding modes are similar to that of DMU-212. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free