A Facial Protocol for the Synthesis of Benzofuran Derivatives by the Reaction of o-Hydroxy Aryl Ketone, Amine and Chloroacetyl Chloride

Bulletin of the Korean chemical society

Chang Liu¹  Ji-Qiang Liu¹  Yong-Sheng Xie¹  Dong-Soo Shin¹  Hua Zuo¹  Jian-Bin Chen¹  Shuai Xia¹  Wen-Liang Dong¹  Xiu-Hua Wang¹ 

关键词: Benzofuran;    o-Hydroxy aryl ketone;    Amine;    Synthesis;    Intramolecular condensation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A facile and effective method has been developed for the synthesis of a novel series of benzofuran derivatives via N-acylation, O-alkylation and intramolecular condensation reactions, starting from readily available substituted o-hydroxy aryl ketone, and chloroacetyl arylamides. This metal-free transition process is characterized by mild reaction conditions, atom economy, short reaction time and a high yield with a decreased amount of by-products.

【 授权许可】

Unknown