Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series:: a structure-activity evaluation study

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:14

Article

Ferreira, ICFR ; Calhelha, RC ; Estevinho, LM ; Queiroz, MJRP

关键词: diarylamines;    antimicrobial activity;    SAR;    benzothiophenes;   

DOI  :  10.1016/j.bmcl.2004.09.038

来源: Elsevier

【 摘 要 】

Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated. (C) 2004 Elsevier Ltd. All rights reserved.

【 授权许可】

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