Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:16

Article

Ferreira, ICFR ; Queiroz, MJRP ; Vilas-Boas, M ; Estevinho, LM ; Begouin, A ; Kirsch, G

关键词: diarylamines;    benzothiophenes;    antioxidant activity;    structure-activity relationships;   

DOI  :  10.1016/j.bmcl.2005.11.035

来源: Elsevier

【 摘 要 】

The antioxidant properties of substituted diarylamines in the benzo[b]thiophene series were evaluated by their reducing power and free radical scavenging activity. The results were compared with those of standards: acid ascorbic for the first method and, BHA and BHT for the second. For both methods it was possible to establish some structure-activity relationships (SARs) based on the position of the arylamination on the benzo[b]thiophene moiety, the presence of different substituents on the phenyl ring (F, 1 or 2 OMe) and on the thiophene ring (H, CO2Et, CO2H). (C) 2005 Elsevier Ltd. All rights reserved.

【 授权许可】

Free