Evaluation of nicotine and cotinine analogs as potential neuroprotective agents for Alzheimer's disease

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:24

Article

Gao, Jie¹  Adam, Bao-Ling¹  Terry, Alvin V., Jr.¹ 

[1] Georgia Regents Univ, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA

关键词: Neuroprotection;    Nicotinic;    Multi-target-directed ligands;    Multifunctional compounds;    Amyloid;    Glutamate;    Excitotoxicity;    Neurodegeneration;    Dementia;    Disease modifying;   

DOI  :  10.1016/j.bmcl.2014.02.008

来源: Elsevier

【 摘 要 】

The currently available therapies for Alzheimer's disease (AD) and related forms of dementia are limited by modest efficacy, adverse side effects, and the fact that they do not prevent the relentless progression of the illness. The purpose of the studies described here was to investigate the neuroprotective effects of the nicotine metabolite cotinine as well as a small series of cotinine and nicotine analogs (including stereoisomers) and to compare their effects to the four clinically prescribed AD therapies. (C) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free