期刊论文详细信息
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 卷:23
Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease
Article
Romero, Alejandro1  Cacabelos, Ramon2  Oset-Gasque, Maria J.3  Samadi, Abdelouahid4  Marco-Contelles, Jose4 
[1] Univ Complutense Madrid, Fac Vet Med, Dept Pharmacol & Toxicol, E-28040 Madrid, Spain
[2] Inst CNS Disorders & Genom Med, EuroEspes Biomed Res Ctr, Corunna 15166, Spain
[3] Univ Complutense Madrid, Fac Pharm, Dept Biochem & Mol Biol 2, E-28040 Madrid, Spain
[4] Inst Gen Organ Chem CSIC, Med Chem Lab, Madrid 28006, Spain
关键词: Tacrine;    Cholinesterase inhibitors;    Multi-target-directed ligands;    New tacrine hybrids;    Hepatotoxicity;    Alzheimer's disease;   
DOI  :  10.1016/j.bmcl.2013.02.017
来源: Elsevier
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【 摘 要 】

A summary of the recently published efforts on tacrine derivatives as a renewed potential therapeutic approach for the treatment of Alzheimer's disease is presented. (C) 2013 Elsevier Ltd. All rights reserved.

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