Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:24

Article

Ding, Kejia¹  Wang, Annie¹  Boerneke, Mark A.¹  Dibrov, Sergey M.¹  Hermann, Thomas¹ 

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

关键词: Antivirals;    HCV;    RNA targeting;    Translation inhibitor;   

DOI  :  10.1016/j.bmcl.2014.05.009

来源: Elsevier

【 摘 要 】

We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The design of the compounds was guided by the co-crystal structure of a benzimidazole viral translation inhibitor in complex with the RNA target. Structure-binding activity relationships of aryl-substituted benzimidazole ligands were established that were consistent with the crystal structure of the translation inhibitor complex. (C) 2014 Elsevier Ltd. All rights reserved.

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