2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:24

Article

Rynearson, Kevin D.¹  Charrette, Brian¹  Gabriel, Christopher¹  Moreno, Jesus¹  Boerneke, Mark A.¹  Dibrov, Sergey M.¹  Hermann, Thomas¹ 

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

关键词: Antivirals;    HCV;    RNA target;    Translation inhibitor;   

DOI  :  10.1016/j.bmcl.2014.05.088

来源: Elsevier

【 摘 要 】

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated. (C) 2014 Elsevier Ltd. All rights reserved.

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