Dipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:23

Article

Scopel, Marina¹  Abraham, Wolf-Rainer²  Henriques, Amelia T.¹  Macedo, Alexandre J.^1,3 

[1] Univ Fed Rio Grande do Sul, Dept Prod Mat Prima, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil

[2] Helmholtz Ctr Infect Res, Braunschweig, Germany

[3] Univ Fed Rio Grande do Sul, Ctr Biotecnol, BR-91501970 Porto Alegre, RS, Brazil

关键词: cis-cyclo(Leucyl-Tyrosyl);    Staphylococcus epidermidis;    Biofilm;    Marine-derived fungi;   

DOI  :  10.1016/j.bmcl.2012.12.020

来源: Elsevier

【 摘 要 】

Infections associated to microbial biofilms are involved in 80% of human infections and became a challenge concerning public health. Infections related to Staphylococcus epidermidis biofilms are presently commonly associated to medical devices, increasing treatment costs for this type of infection. Alternatives to eliminate this kind of disease have been employed in screening programs using diverse marine-derived fungi source of bioactive compounds capable to combat biofilm formation. In this work was isolated the dipeptide cis-cyclo(Leucyl-Tyrosyl) from a sponge associated Penicillium sp. possessing a remarkable inhibition up to 85% of biofilm formation without interfering with bacterial growth, confirmed by scanning electron microscopy. This is the first demonstration that cis-cyclo(Leucyl-Tyrosyl) is able to specifically inhibit biofilm formation adding another aspect to the broad spectrum of bioactivities of cyclic dipeptides. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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