Synthesis and antimicrobial studies of novel derivatives of 4-(4-formy1-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:27

Article

Allison, Devin¹  Delancey, Evan¹  Ramey, Hunter¹  Williams, Conrad¹  Alsharif, Zakeyah Ali¹  Al-Khattabi, Hessa¹  Ontko, Allyn¹  Gilmore, David²  Alam, Mohammad A.¹ 

[1] Arkansas State Univ, Coll Sci & Math, Dept Chem & Phys, Jonesboro, AR 72467 USA

[2] Arkansas State Univ, Dept Biol Sci, Coll Sci & Math, Jonesboro, AR 72467 USA

关键词: Pyrazole;    Antimicrobials;    Resistant;    Hydrazone;    Antibacterial;    Acinetobacter baumannii;    Methicillin-resistant Staphylococcus aureus (MRSA);   

DOI  :  10.1016/j.bmcl.2016.12.068

来源: Elsevier

【 摘 要 】

Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the world is moving toward a post-antibiotic era, in which normal infections or minor injuries may become fatal. In an effort to find new agents, we report the synthesis and antimicrobial activities of 40 novel 1,3-diphenyl pyrazole derivatives. These compounds have shown zones of growth inhibition up to 85 mm against Acinetobacter baumannii. We tested the active compounds against this Gram-negative bacterium in minimum inhibitory concentration (MIC) tests and found activity with concentration as low as 4 mu g/mL. Published by Elsevier Ltd.

【 授权许可】

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