Radioligands targeting purinergic P2X7 receptor

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:30

Article

Zheng, Qi-Huang¹ 

[1] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, 1345 West 16th St,Room 208, Indianapolis, IN 46202 USA

关键词: Purinergic P2X7 receptor (P2X7R);    Radioligands;    Drug discovery;    Molecular imaging;    Positron emission tomography (PET);    Single photon emission computed tomography (SPECT);   

DOI  :  10.1016/j.bmcl.2020.127169

来源: Elsevier

【 摘 要 】

The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic target as well as molecular imaging target. This brief digest highlights the radioligands targeting P2X7R recently developed in drug discovery and molecular imaging agent development.

【 授权许可】

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