期刊论文详细信息
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 卷:21
Sensitive luciferin derived probes for selective carboxypeptidase activity
Article
Chang, Yu-Cheng1  Chao, Pei-Wen1  Tung, Ching-Hsuan1 
[1] Methodist Hosp, Res Inst, Weill Cornell Med Coll, Dept Radiol, Houston, TX 77030 USA
关键词: Luciferin;    Carboxypeptidase A;    Carboxypeptidase G;    Luciferase;    Glutamic acid;    Tyrosine;   
DOI  :  10.1016/j.bmcl.2011.05.023
来源: Elsevier
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【 摘 要 】

Highly selective luminescent probes, QLUC-TYR and LUC-GLU, for detection of carboxypeptidase activity were synthesized. Caged substrates were first cleaved by corresponding carboxypeptidases, and then they were activated by luciferase to emit light. Enzymatic activities of biologically important carboxypeptidases can be determined using this technology. (C) 2011 Elsevier Ltd. All rights reserved.

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