Halting metastasis through CXCR4 inhibition

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:23

Review

Ramsey, Deborah M.¹  McAlpine, Shelli R.¹ 

[1] Univ New S Wales, Dept Chem, Sydney, NSW 2052, Australia

关键词: CXCR4;    SDF-1;    Metastasis;    Cancer;    Heat shock protein 90;   

DOI  :  10.1016/j.bmcl.2012.10.138

来源: Elsevier

【 摘 要 】

Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4-SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches are currently being developed to inhibit this pathway, and several candidates are now in clinical trials. Continued exploration of CXCR4 inhibitors will generate compounds that have improved activity over current candidates. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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