Expression and significance of SDF-1 and its receptor CXCR4 in the retina of pregnant rats after optic nerve injury:

European Journal of Inflammation

TiegangLiu¹ 

关键词: CXCR4;    optic nerve injury;    pregnant rats;    retina;    SDF-1;   

DOI  :  10.1177/2058739218819675

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Stromal cell–derived factor 1 (SDF-1) and its receptor CXCR4 have shown to play a role in embryonic development process, regulation of hematopoiesis, mediating immunology response, inflammatory reaction, and metastasis of malignant tumor. Recently, SDF-1 and CXCR4 are also closely related to retinal neovascularization. This study was to investigate the expression of SDF-1 and CXCR4 in the retina after optic nerve injury in pregnant rats so as to reveal its significance. A total of 12 pregnant rats were randomly divided into normal group and experimental group (after 5 days of optic nerve injury), six rats in each group; expressions of SDF-1 as well as CXCR4 in rat retina were detected by immunofluorescence staining and western blot assay. The result of immunofluorescence staining showed that the relative gray scale values of SDF-1 and CXCR4 in the experimental group were significantly higher than those in the normal group (P < 0.05), and the result of Western blot assay showed that the expression levels of SDF-1 and CXCR4 in the experimental group were significantly higher than those in the normal group (P < 0.05). In conclusion, SDF-1 and its receptor CXCR4 have abnormal expression in the retina of pregnant rats after optic nerve injury, which may be involved in the occurrence and development of optic nerve injury.

【 授权许可】

CC BY-NC