Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:18

Article

Gates, Kent S.¹ 

[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

关键词: Protein tyrosine phosphatase;    Peroxides;    Hydroperoxides;    Enzyme inactivation;   

DOI  :  10.1016/j.bmcl.2008.06.029

来源: Elsevier

【 摘 要 】

Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide. (C) 2008 Elsevier Ltd. All rights reserved.

【 授权许可】

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