Analysis of oxidative stress during the menstrual cycle

Reproductive Biology and Endocrinology

Annarosa Finco¹  Maria Rosaria Cesarone²  Gianni Belcaro²  Umberto Cornelli³ 

[1] Cor Con. International Srl Res Department, Parma, PR, Italy;University of Chieti, Chieti, Italy;Loyola University School of Medicine-Chicago, Chicago, USA

关键词: Progestagens;    Estrogens;    d-ROMs test;    Hydroperoxides;    Eumenorrheic;   

Others  :  810951
DOI  :  10.1186/1477-7827-11-74

 received in 2013-04-19, accepted in 2013-07-29,  发布年份 2013

【 摘 要 】

Background

Few data concerning the oxidative stress (OS) in plasma during the entire menstrual cycle of eumenorrheic women are available.

Methods

OS was assessed in 20 healthy volunteers during the phase of the menstrual cycle by determining the plasmatic hydroperoxides levels (d-ROMs test). The assessment was performed every three days, starting from the first day (t1) up the end of the menstrual phase (t27). Concomitantly, the estrogen (E2) and progestin (P4) levels were determined at the same time intervals.

Results

From a base value (t1) of 284 +/− 38.0 CARR.U., which is essentially within the normal range (<300 Carratelli units or CARR.U.), the OS levels progressively increased to 378 +/− 115 CARR.U. at t15, and then slightly decreased over the subsequent time but with average values >300 CARR.U. Analysis of the E2 levels showed that the maximum OS values were noticed near the estrogen peak, while remaining above the base levels, and then decreased during the progestin phase until returning to normal at the end of the menstrual cycle.

Conclusions

It may concludes that the healthy women go into OS for 2/3 of the menstrual cycle.

【 授权许可】

   
2013 Cornelli et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Serviddio G, Loverro G, Vicino M, Prigigallo F, Grattagliano I, Altomare E, Vendemiale G: Modulation of endometrial balance during the menstrual cycle: relation with sex hormones. J Clin Endocrinol Metab 2002, 87:2843-2848.
• [2]Browne RW, Bloom MS, Schisterman EF, Hovey K, Trevisan M, Wu C, Liu A, Wactawski-Wende J: Analytical and biological variation of biomarkers of oxidative stress during the menstrual cycle. Biomarkers 2008, 13:160-183.
• [3]Cornelli U, Belcaro G, Finco A: The oxidative stress balance measured in humans with different markers, following a single oral antioxidants supplementation or a diet poor of antioxidants. J Chem Dermatol Sci Appl 2011, 1:64-70.
• [4]Massafra C, Gioia D, De Felice C, Picciolini E, De Leo V, Bonifazi M, Bernabei A: Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle. J Endocrinol 2000, 167:447-452.
• [5]Santanam N, Shern-Brewer R, McClatchey R, Castellano PZ, Murphy AA, Voelkel S, Parthasarathy S: Estradiol as an antioxidant: incompatible with its physiological concentrations and function. J Lipid Res 1998, 39:2111-2118.
• [6]Cesarone MR, Belcaro G, Carratelli M, Cornelli U, De Sanctis MT, Incandela L, Barsotti A, Terranova R, Nicolaides A: A simple test to monitor oxidative stress. Int Angiol 1999, 18:127-130.
• [7]Cornelli U, Terranova R, Luca S, Cornelli M, Alberti A: Bioavailability and antioxidant activity of some food supplements in men and women using the d-ROMs test as a marker of oxidative stress. J Nutr 2001, 131:3208-3211.
• [8]Brigelius-Flohè R, Flohé L: Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 2011, 15:2335-2381.
• [9]Loose DS, Stancel GM: Estrogens and Progestins. In Goodman & Gilman's the pharmacological basis of therapeutics. 11th edition. Edited by Brunton LL, Lazo JS, Parker KL. New York: McGraw-Hill; 2006:1541-1571.
• [10]Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK: Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Soc Acad Sci USA 2001, 98:2604-2609.
• [11]Cameron IT, Campbell S: Nitic oxide in the endometrium. Human Repr Update 1998, 4:565-589.
• [12]Foidart JM, De Groote D, Claesen J, Gerday C, Balteau B, Pintiaux A, Perrier d'Hauterive S: Effect of oral contraception with ethiylestradiol and drospirenone on oxidative stress in women 18–35 years old. Contraception 2009, 80:187-193.
• [13]Pincemail J, Vanbelle S, Gaspard U, Collette G, Haleng J, Cheramy-Bien JP, Charlier C, Chapelle JP, Giet D, Albert A, et al.: Effect of different contraceptive methods on the oxidative status in women aged 40–48 years from ELAN study in the province of Liège- Belgium. Human Reprod 2007, 22:2335-2343.
• [14]Sack MN, Rader DJ, O Cannon R: Oestrogens and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 1994, 343:269-270.
• [15]Sugioka K, Shimosegawa Y, Nakano M: Estrogerns as natural antioxidants of membrane phospholipid peroxidation. FEBS 1987, 210:37-39.
• [16]Shern-Brewer R, Santanam N, Wetzstein C, White-Welkley J, Parthasarathy S: Exercise and cardiovascular disease a new perspective. Arteriosc Thromb Vasc Biol 1998, 18:1181-1187.
• [17]Chiang K, Parthasarathy S, Santanan N: Estrogen, neutrophils oxidation. Life Sci 2004, 75:2425-2438.
• [18]Swaim MW, Pizzo SV: Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors. J Leuk Biol 1988, 43:365-379.
• [19]Bani D: Relaxin as a natural agent for vascular health. Vasc Health Risk Manag 2008, 4:515-524.