Analysis of oxidative stress during the menstrual cycle

Reproductive Biology and Endocrinology

Research

Annarosa Finco¹  Umberto Cornelli²  Gianni Belcaro³  Maria Rosaria Cesarone³ 

[1] Cor Con. International Srl Res Department, Parma, PR, Italy;Loyola University School of Medicine, Chicago, Chicago, USA;University of Chieti, Chieti, Italy;

关键词: Eumenorrheic;    Hydroperoxides;    d-ROMs test;    Estrogens;    Progestagens;   

DOI  :  10.1186/1477-7827-11-74

 received in 2013-04-19, accepted in 2013-07-29,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundFew data concerning the oxidative stress (OS) in plasma during the entire menstrual cycle of eumenorrheic women are available.MethodsOS was assessed in 20 healthy volunteers during the phase of the menstrual cycle by determining the plasmatic hydroperoxides levels (d-ROMs test). The assessment was performed every three days, starting from the first day (t1) up the end of the menstrual phase (t27). Concomitantly, the estrogen (E2) and progestin (P4) levels were determined at the same time intervals.ResultsFrom a base value (t1) of 284 +/− 38.0 CARR.U., which is essentially within the normal range (<300 Carratelli units or CARR.U.), the OS levels progressively increased to 378 +/− 115 CARR.U. at t15, and then slightly decreased over the subsequent time but with average values >300 CARR.U. Analysis of the E2 levels showed that the maximum OS values were noticed near the estrogen peak, while remaining above the base levels, and then decreased during the progestin phase until returning to normal at the end of the menstrual cycle.ConclusionsIt may concludes that the healthy women go into OS for 2/3 of the menstrual cycle.

【 授权许可】

Unknown   
© Cornelli et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.