Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:22

Article

Midtkandal, Rebecca R.¹  Redpath, Philip¹  Trammell, Samuel A. J.²  Macdonald, Simon J. F.³  Brenner, Charles²  Migaud, Marie E.¹ 

[1] Queens Univ Belfast, John King Lab, Sch Pharm, Belfast BT9 7BL, Antrim, North Ireland

[2] Univ Iowa, Dept Biochem, Carver Coll Med, Iowa City, IA 52242 USA

[3] GlaxoSmithKline, Stevenage SG1 2NY, Herts, England

关键词: C-Nucleoside;    Benzamide riboside;    Intramolecular cyclisation;    Inosine monophosphate dehydrogenase;    Nicotinamide adenine dinucleotide;   

DOI  :  10.1016/j.bmcl.2012.06.069

来源: Elsevier

【 摘 要 】

2-Deoxy-C-nucleosides are a subcategory of C-nucleosides that has not been explored extensively, largely because the synthesis is less facile. Flexible synthetic procedures giving access to 2-deoxy-C-nucleosides are therefore of interest. To exemplify the versatility and highlight the limitations of a synthetic route recently developed to that effect, the first synthesis of 2-deoxy benzamide riboside is reported. Biological properties of this novel C-nucleoside are also discussed. (c) 2012 Elsevier Ltd. All rights reserved.

【 授权许可】

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