A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and other neurological diseases

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:9

Article

Mazzucco, S ; Matà, S ; Vergelli, M ; Fioresi, R ; Nardi, E ; Mazzanti, B ; Chelli, M ; Lolli, F ; Ginanneschi, D ; Pinto, F ; Massacesi, L ; Papini, AM

关键词: MOG;    glycopeptides;    multiple sclerosis;    antibodies;   

DOI  :  10.1016/S0960-894X(98)00698-2

来源: Elsevier

【 摘 要 】

Glycopeptides of hMOG(30-50) containing a glucosyl moiety on the side-chains of Asn, Ser or Hyp at position 31 were synthesised. Antibody titres to hMOG(30-50) and to its glucoderivatives were measured by ELISA in sera of patients affected by different neurological diseases. Anti-hMOG(30-50) antibodies were detected only using the glycopeptide [Asn(31)(N-Glc)]hMOG(30-50). (C) 1999 Elsevier Science Ltd. All rights reserved.

【 授权许可】

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