Heterocyclic aminoparthenolide derivatives modulate G2-M cell cycle progression during Xenopus oocyte maturation

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

卷:24

Article

Janganati, Venumadhav¹  Penthala, Narsimha Reddy¹  Cragle, Chad E.²  MacNicol, Angus M.²  Crooks, Peter A.¹ 

[1] Univ Arkansas Med Sci, Dept Pharmaceut Sci, Coll Pharm, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA

关键词: Parthenolide;    Oocyte maturation;    Progesterone;    Michael addition;    Heterocyclic amines;   

DOI  :  10.1016/j.bmcl.2014.02.067

来源: Elsevier

【 摘 要 】

Aminoparthenolide derivatives have been prepared by reaction of parthenolide with various heterocyclic amines to afford corresponding Michael addition products. These novel compounds were evaluated for their modulatory effects on Xenopus oocyte maturation. Two compounds, 6e and 6f, were identified that promote G2-M cell cycle progression. (c) 2014 Elsevier Ltd. All rights reserved.

【 授权许可】

Free