Cocaine exposure during the early postnatal period diminishes medial frontal cortex Gs coupling to dopamine D1-like receptors in adult rat

NEUROSCIENCE LETTERS

卷:438

Article

Zhao, Ning¹  Wang, Hoau-Yan²  Dow-Edwards, Diana¹ 

[1] Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA

[2] CUNY, Sch Med, Sophie Davis Sch Biomed Educ, Dept Physiol & Pharmacol, New York, NY 10021 USA

关键词: dopamine;    cocaine;    receptor;    postnatal;    medial frontal cortex;    caudate/putamen;   

DOI  :  10.1016/j.neulet.2008.04.014

来源: Elsevier

【 摘 要 】

The effect of cocaine exposure during early postnatal ages on coupling of dopamine (DA) D-1- and D-2-like receptors to their respective Gs/olf and Gi was examined in striatum and medial frontal cortex (MFC). Sprague-Dawley rats were subcutaneously injected with either 50 mg/kg cocaine or vehicle during postnatal day (PnD) 11-20 and dopaminergic D-1- and D-2-like receptor signaling was evaluated at PnD 60. Results showed that cocaine exposure did not affect the magnitude of both DA D-1- and D-2-like receptor coupling to their respective Gs/olf and Gi in striatum. However, in the medial frontal cortex, the basal and the DA D-1-like receptor and Gs association were reduced in cocaine-exposed brains. However, there was no change in basal or DA D-2-like receptor-Gi linkage in medial frontal cortex. Since frontal cortex plays a critical role in regulating cognition and working memory, disruption of DA-modulated circuits or alteration of dopaminergic activity resulting from postnatal cocaine exposure may result in abnormal responses to environmental challenges leading to long-term behavioral changes. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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