Individual differences in cocaine's locomotor activating effects predicts reward-directed behavior

cocaine;individual differences;addiction

Venheim, Emily R. ; Gulley ; Joshua M.

关键词: cocaine;    individual differences;    addiction;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/24033/Venheim_Emily.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Humans exhibit marked individual differences in susceptibility to develop drugdependence. Addiction-like behaviors have been modeled in rodents as well with similarindividual variability in the development of addiction-like behaviors. One potential mechanismthat could differentiate addiction-vulnerable from addiction-resistant individuals is sensitivity toreward-paired cues. Pavlovian-instrumental transfer (PIT) is a paradigm that assesses the extentto which reward cues can initiate previously unpaired instrumental responding for a commonreward. To examine the potential that sensitivity to reward-paired cues is a mechanismdifferentiating individuals with a propensity to develop addiction-like behaviors, we used arodent model known to differ in initial responsiveness to cocaine as well as in behaviorsimplicated in ‘addiction-vulnerability’. We hypothesize that rodents displaying the ‘addiction-vulnerable’phenotype will initiate instrumental responding to a greater degree when presentedwith cues associated with reward than their counterparts.