Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat

NEUROSCIENCE LETTERS

卷:231

Article

关键词: brain trauma;    remacemide hydrochloride;    lesion volume;    memory;    neuroprotection;    2,3,5-triphenyltetrazolium chloride;   

DOI  :  10.1016/S0304-3940(97)00551-X

来源: Elsevier

【 摘 要 】

We evaluated the therapeutic effects of remacemide hydrochloride, an N-methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intravenous (i.v.) administration 15 min following injury of remacemide hydrochloride at both 25 and 10 mg/kg significantly reduced posttraumatic cortical lesion volume (P < 0.05), measured at 48h postinjury using a tetrazolium salt tissue staining technique. However, neither of these doses nor the dosing regimen of 25 mg/kg i.v. 15 min postinjury plus a subcutaneous infusion over 24h of 20 mg/kg remacemide hydrochloride improved posttraumatic memory function determined by a Morris water maze paradigm. (C) 1997 Elsevier Science Ireland Ltd.

【 授权许可】

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