Changes in serum neurofilament light chain levels following narrowband ultraviolet B phototherapy in clinically isolated syndrome

Brain and Behavior

Robyn M. Lucas¹  Aleksandra Maceski²  Jens Kuhle²  Stephanie Trend³  Katherine M. A. Roberts³  Allan G. Kermode³  Frank L. Mastaglia³  William M. Carroll³  Marzena J. Fabis‐Pedrini³  Prue H. Hart⁴  Anderson P. Jones⁴ 

[1] National Centre for Epidemiology & Population Health Research School of Population Health Australian National University Canberra Australia;Neurology Clinic and Policlinic MS Centre and Research Centre for Clinical Neuroimmunology and Neuroscience Basel University of Basel Basel Switzerland;Perron Institute for Neurological and Translational Science University of Western Australia Perth Australia;Telethon Kids Institute University of Western Australia Perth Australia;

关键词: clinically isolated syndrome;    lesion volume;    multiple sclerosis;    neurofilament light chain;    ultraviolet B;   

DOI  :  10.1002/brb3.2494

来源: DOAJ

【 摘 要 】

Abstract Objective To determine whether serum neurofilament light chain (sNfL) levels are suppressed in patients with the clinically isolated syndrome (CIS) following narrowband ultraviolet B phototherapy (UVB‐PT). Methods sNfL levels were measured using a sensitive single‐molecule array assay at baseline and up to 12 months in 17 patients with CIS, 10 of whom received UVB‐PT, and were compared with healthy control (HC) and early relapsing remitting multiple sclerosis (RRMS) group. sNfL levels were correlated with magnetic resonance imaging total lesion volume (LV) determined using icobrain version 4.4.1 and with clinical outcomes. Results Baseline median sNfL levels were significantly higher in the CIS (20.6 pg/mL, interquartile range [IQR] 13.7–161.4) and RRMS groups (36.6 pg/ml [IQR] 16.2–212.2) than in HC (10.7 pg/ml [IQR] 4.9–21.5) (p = .012 and p = .0002, respectively), and were strongly correlated with T2 and T1 LV at 12 months (r = .800; p = .014 and r = .833; p = .008, respectively) in the CIS group. Analysis of changes in sNfL levels over time in the CIS group showed a significant cumulative suppressive effect of UVB‐PT in the first 3 months (UVB‐PT −10.6% vs non‐UVB‐PT +58.3%; p = .04) following which the levels in the two groups converged and continued to fall. Conclusions Our findings provide the basis for further studies to determine the utility of sNfL levels as a marker of neuro‐axonal damage in CIS and early MS and for assessing the efficacy of new therapeutic interventions such as UVB‐PT.

【 授权许可】

Unknown