Innexin expression in electrically coupled motor circuits

NEUROSCIENCE LETTERS

卷:695

Review

Otopalik, Adriane G.¹  Lane, Brian²  Schulz, David J.²  Marder, Eve¹ 

[1] Brandeis Univ, Volen Ctr & Biol Dept, Waltham, MA 02454 USA

[2] Univ Missouri Columbia, Div Biol Sci, Columbia, MO 65211 USA

关键词: Stomatogastric ganglion;    Cardiac ganglion;    Crustacean;    Central pattern generators;    Neuronal homeostasis;   

DOI  :  10.1016/j.neulet.2017.07.016

来源: Elsevier

【 摘 要 】

The many roles of innexins, the molecules that form gap junctions in invertebrates, have been explored in numerous species. Here, we present a summary of innexin expression and function in two small, central pattern generating circuits found in crustaceans: the stomatogastric ganglion and the cardiac ganglion. The two ganglia express multiple innexin genes, exhibit varying combinations of symmetrical and rectifying gap junctions, as well as gap junctions within and across different cell types. Past studies have revealed correlations in ion channel and innexin expression in coupled neurons, as well as intriguing functional relationships between ion channel conductances and electrical coupling. Together, these studies suggest a putative role for innexins in correlating activity between coupled neurons at the levels of gene expression and physiological activity during development and in the adult animal. (C) 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

【 授权许可】

Free