An analysis of the CatWalk XT and a composite score to assess neurofunctional deficits after photothrombosis in mice

NEUROSCIENCE LETTERS

卷:751

Article

Baermann, J.^1,2  Walter, H. L.^1,2  Pikhovych, A.^1,2  Endepols, H.^1,3,4,5  Fink, G. R.^1,2,6  Rueger, M. A.^1,2,6  Schroeter, M.^1,2 

[1] Univ Cologne, Fac Med, Kerpener Str 62, D-50937 Cologne, Germany

[2] Univ Hosp Cologne, Dept Neurol, Kerpener Str 62, D-50937 Cologne, Germany

[3] Univ Hosp Cologne, Dept Nucl Med, Kerpener Str 62, D-50937 Cologne, Germany

[4] Univ Hosp Cologne, Inst Radiochem & Expt Mol Imaging, Kerpener Str 62, D-50937 Cologne, Germany

[5] Forschungszentrum Julich, Inst Neurosci & Med, Nucl Chem INM 5, Wilhelm Johnen Str, D-52428 Julich, Germany

[6] Forschungszentrum Julich, Inst Neurosci & Med, Spatial Cognit INM 3, Wilhelm Johnen Str, D-52428 Julich, Germany

关键词: Photothrombotic stroke;    Cortical stroke;    Photothrombosis;    Hemisyndrome;    Neuroscore;    CatWalk XT;    Behaviour;    Gait analysis;    Functional deficit assessment;    Forelimb impairment;    Coordinative dysfunction;    Central pattern generators;   

DOI  :  10.1016/j.neulet.2021.135811

来源: Elsevier

【 摘 要 】

The purpose of this study was to evaluate CatWalk's capability for assessing the functional outcome after photothrombotic stroke affecting the motor cortex of mice. Mice were tested up to 21 days after photothrombosis or sham surgery using CatWalk, and a composite score assessing functional deficits (neuroscore). The neuroscore demonstrated deficits of the contralateral forelimb for more than two weeks after stroke. There were no asymmetric or coordinative dysfunctions of limbs detected by CatWalk. However, CatWalk data revealed impairment of locomotion speed and its depending parameters for one-week after stroke in strong correlation to the neuroscore. Data suggest that the composite neuroscore allows to more sensitively and precisely specify and quantify photothrombosis-induced hemisyndromes than CatWalk.

【 授权许可】

Free