Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence

NEUROSCIENCE LETTERS

卷:440

Article

Lohoff, Falk W.¹  Bloch, Paul J.¹  Weller, Andrew E.¹  Nall, Aleksandra H.¹  Doyle, Glenn A.¹  Buono, Russell J.³  Ferraro, Thomas N.¹  Kampman, Kyle M.²  Pettinati, Helen M.²  Dackis, Charles A.²  Oslin, David W.²  O'Brien, Charles P.²  Berrettini, Wade H.¹ 

[1] Univ Penn, Sch Med, Ctr Neurobiol & Behav, Translat Res Labs,Dept Psychiat, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Treatment Res Ctr, Dept Psychiat, Philadelphia, PA 19104 USA

[3] Vet Affairs Med Ctr, Res Serv, Coatesville, PA USA

关键词: genetics;    association study;    haplotype;    addiction;    substance abuse;    cocaine;   

DOI  :  10.1016/j.neulet.2008.05.073

来源: Elsevier

【 摘 要 】

Dopaminergic brain systems have been implicated to play a major role in drug reward, thus making genes involved in these circuits plausible candidates for susceptibility to substance use disorders. The cocaine- and amphetamine-regulated transcript peptide (CARTPT) is involved in reward and feeding behavior and has functional characteristics of an endogenous psychostimulant. In this study we tested the hypothesis that variation in the CARTPT gene increases susceptibility to cocaine dependence in individuals of African descent. Genotypes of three HapMap tagging SNPs (rs6894758; rs11575893; rs17358300) across the CARTPT gene region were obtained in cocaine dependent individuals (n = 348) and normal controls (n = 256). All subjects were of African descent. There were no significant differences in allele, genotype or haplotype frequencies between cases and controls for any of the tested SNPs. Our results do not support an association of the CARTPT gene with cocaine dependence; however, additional studies using larger samples, comprehensive SNP coverage, and different populations are necessary to conclusively rule out CARTPT as a contributing factor in the etiology of cocaine dependence. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

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