Reduced serum concentrations of brain-derived neurotrophic factor (BDNF) in transsexual Brazilian men

NEUROSCIENCE LETTERS

卷:630

Article

Vaitses Fontanari, Anna Martha¹  Costa, Angelo Brandelli²  Aguiar, Bianca¹  Tusset, Cintia³  Andreazza, Tahiana¹  Schneider, Maiko¹  da Rosa, Eduarda Dias¹  Borba Soll, Bianca Machado¹  Schwarz, Karine¹  da Silva, Dhiordan Cardoso¹  Borba, Andre Oliveira⁵  Mueller, Andressa¹  Massuda, Raffael⁶  Rodrigues Lobato, Maria Ines⁴ 

[1] Univ Fed Rio Grande do Sul, Dept Psychiat, Hosp Clin Porto Alegre, BR-90046900 Porto Alegre, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande Sul Porto Ale, Psychol Grad Program, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Endocrinol, BR-90046900 Porto Alegre, RS, Brazil

[4] Hosp Clin Porto Alegre, Dept Psychiat, Porto Alegre, RS, Brazil

[5] Univ Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, Brazil

[6] Univ Fed Parana UFPR, Dept Psychiat, Porto Alegre, RS, Brazil

关键词: Transsexuality;    Transgender;    Transsexualism;    Gender dysphoria;    Neurotrophin;    BDNF;   

DOI  :  10.1016/j.neulet.2016.07.034

来源: Elsevier

【 摘 要 】

Serum BDNF levels are significantly decreased in transsexual Brazilian women when compared to cis sexual men. Since transsexual men are also exposed to chronic social stress and have a high prevalence of associated psychopathologies, it is plausible to inquire if BDNF serum levels are altered in transsexual men as well. Therefore, our objective was to evaluate differences in BDNF serum level of transsexual men when compared to cis-sexual men and women. Our sample comprises 27 transsexual men, 31 cis-sexual women and 30 cis-sexual men recruited between 2011 and 2015. We observed that BDNF serum concentration is decreased in transsexual men comparing to cis-sexual men and women. Cross-sex hormone treatment, chronic social stress or long-term gender dysphoria (GD) could explain the variation found in BDNF serum levels. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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