Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence

NEUROSCIENCE LETTERS

卷:400

Article

Nomura, Akira ; Ujike, Hiroshi ; Tanaka, Yuji ; Otani, Kyohei ; Morita, Yukitaka ; Kishimoto, Makiko ; Morio, Akiko ; Harano, Mutsuo ; Inada, Toshiya ; Yamada, Mitsuhiko ; Komiyama, Tokutaro ; Sekine, Yoshimoto ; Iwata, Nakao ; Sora, Ichiro ; Iyo, Masaomi ; Ozaki, Norio ; Kuroda, Shigetoshi

关键词: addiction;    psychostimulant;    genetics;    methamphetamine;    opioid receptor;   

DOI  :  10.1016/j.neulet.2006.02.038

来源: Elsevier

【 摘 要 】

Previous studies have indicated that genetic factors substantially affect development of substance use disorders, including methamphetamine dependence. Prodynorphin (PDYN) is an opioid peptide precursor that yields dynorphins, endogenous kappa opioid-receptoragonists that play important roles in substance abuse. A physiologically active polymorphism of 1-4 repeats of a 68-bp element in the promoter region of the PDYN gene has been identified. We analyzed this polymorphism of the PDYN gene by a case-control association study in 143 patients with methamphetamine dependence and 209 healthy controls in the Japanese population. A 3- or 4-repeat allele in the PDYN gene promoter was found significantly more frequently in patients with methamphetamine dependence than in controls (chi(2) = 9.45, p = 0.0021). A 3- or 4-repeat allele in the PDYN gene promoter, which was shown to produce significantly higher transcription activity of the PDYN gene than a 1- or 2-repeat allele, is a genetic risk factor for development of methamphetamine dependence (odds ratio: 1.83, 95% CI = 1.24-2.68). (c) 2006 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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