Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei

NEUROSCIENCE LETTERS

卷:498

Article

Boisvert, Joanne P.¹  Boschuetz, Tyler J.¹  Resch, Jon M.¹  Mueller, Christopher R.¹  Choi, SuJean¹ 

[1] Marquette Univ, Dept Biomed Sci, Milwaukee, WI 53201 USA

关键词: Serotonin;    Corticotropin-releasing factor;    Hypothalamus;    Appetite;    mRNA;   

DOI  :  10.1016/j.neulet.2011.05.011

来源: Elsevier

【 摘 要 】

Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight. To examine possible interactions between 5-HT and neuropeptides in appetite control, fenfluramine (200 nmol/0.5 mu l/side) was administered directly into the hypothalamic paraventricular nuclei (PVN) of male rats. Bilateral fenfluramine produced significant hypophagia and increased expression of PVN corticotropin releasing factor (CRF) mRNA and neuropeptide Y (NPY) mRNA in the arcuate nucleus within the first hour after drug administration. Fenfluramine's effects on feeding behavior and mRNA expression were blocked by PVN injections of a 5-HT(1-2) receptor antagonist, metergoline (15 nmo1/0.5 mu l/side). These data suggest that 5-HT neurons targeting hypothalamic paraventricular CRF neurons may participate in an appetite control circuit for reducing food intake. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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