Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes

NEUROSCIENCE LETTERS

卷:522

Article

Ferguson, Toby A.^1,2  Scherer, Steven S.³ 

[1] Temple Univ, Dept Neurol, Philadelphia, PA 19140 USA

[2] Shriners Pediat Res Ctr, Philadelphia, PA 19140 USA

[3] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA

关键词: Astrocytes;    Cell adhesion;    Genetic deletion;    NCAD;    Neurite outgrowth;    Regeneration;   

DOI  :  10.1016/j.neulet.2012.06.013

来源: Elsevier

【 摘 要 】

We examined the neurite outgrowth of sensory neurons on astrocytes following the genetic deletion of N-cadherin (NCAD). Deletion abolished immunostaining for NCAD and the other classical cadherins, indicating that NCAD is likely the only classical cadherin expressed by astrocytes. Only 38% of neurons grown on NCAD-deficient astrocytes for 24 h produced neurites, as compared to 74% of neurons grown on NCAD-expressing astrocytes. Of the neurons that produced neurites, those grown on NCAD-deficient astrocytes had a mean total length of 378 mu m, as compared to 1093 mu m for neurons grown on NCAD-expressing astrocytes. Thus, the loss of NCAD greatly impairs the formation and extension neurites on astrocytes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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