Acupuncture for sleep quality, BDNF levels and immunosenescence: A randomized controlled study

NEUROSCIENCE LETTERS

卷:587

Article

Zuppa, Carina¹  do Prado, Carine H.¹  Wieck, Andrea¹  Zaparte, Aline¹  Barbosa, Andressa¹  Bauer, Moises Evandro^1,2 

[1] Pontifical Catholic Univ Rio Grande do Sul PUCRS, Inst Biomed Res, Lab Immunosenescence, Porto Alegre, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande do Sul, Fac Biosci, BR-90610000 Porto Alegre, RS, Brazil

关键词: Aging;    Depression;    Stress;    Lymphocytes;    Acupuncture;    Immunity;   

DOI  :  10.1016/j.neulet.2014.12.016

来源: Elsevier

【 摘 要 】

Poor sleep in elderly populations is associated with detrimental neuropsychological, and physiological changes including premature immunosenescence and reduced brain derived neurotrophic factor (BDNF). Here, we evaluated the effects of acupuncture on sleep quality, psychological distress and immunosenescence in elderly, as well as effects on BDNF levels. Forty-eight community-dwelling elderly were randomized into true or placebo acupuncture, and intervention consisted of ten sessions. Sleep quality, depression and stress scores were evaluated by the Pittsburgh sleep quality index (PSQI), beck depression inventory (BDI II) and perceived stress scale (PSS), respectively, before and after the intervention. Lymphocyte subsets commonly associated with stress, sleep impairment and immunosenescence were phenotyped by flow cytometry. BDNF plasma levels were assessed by ELISAs. Acupuncture was highly effective for improving sleep quality (-53.23%; p <0.01), depression (-48.41%; p <0.01), and stress (-25.46%; p <0.01). However, neither lymphocyte subpopulations nor BDNF levels changed following the intervention. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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