Prospective association between major depressive disorder and leukocyte telomere length over two years

PSYCHONEUROENDOCRINOLOGY

卷:90

Article

Vance, Mary C.^1,2  Bui, Eric^3,4  Hoeppner, Susanne S.^3,4  Kovachy, Benjamin⁴  Prescott, Jennifer⁴  Mischoulon, David^3,4  Walton, Zandra E.⁸  Dong, Melissa³  Nadal, Mireya F.^3,4  Worthington, John J.^3,4  Hoge, Elizabeth A.⁵  Cassano, Paolo^3,4  Orr, Esther H.⁹  Fava, Maurizio^3,4  de Vivo, Immaculata⁴  Wong, Kwok-Kin^4,6,7  Simon, Naomi M.^3,4,7 

[1] Univ Michigan, Ann Arbor, MI 48109 USA

[2] VA Ann Arbor Healthcare Syst, Ann Arbor, MI USA

[3] Massachusetts Gen Hosp, Boston, MA 02114 USA

[4] Harvard Sch Publ Hlth, Boston, MA USA

[5] Georgetown Univ, Med Ctr, Washington, DC 20057 USA

[6] Dana Farber Canc Inst, Boston, MA 02115 USA

[7] NYU, Sch Med, New York, NY 10003 USA

[8] Univ Penn, Philadelphia, PA 19104 USA

[9] Brigham & Womens Hosp, Boston, MA 02115 USA

关键词: Telomeres;    Depression;    Aging;    Prospective;    Stress;    Anxiety;   

DOI  :  10.1016/j.psyneuen.2018.02.015

来源: Elsevier

【 摘 要 】

Background: Reduced leukocyte telomere length (LTL) has been found to be associated with multiple common age-related diseases, including heart disease, diabetes, and cancer. A link has also been suggested between shortened LTL and major depressive disorder (MDD), suggesting that MDD may be a disease of accelerated aging. This prospective, longitudinal study examined the association between depression diagnosis at baseline and change in LTL over two years in a well-characterized sample of N = 117 adults with or without MDD at baseline, using rigorous entry criteria. Methods: Participants aged 18-70 were assessed with validated instruments by trained, doctoral-level clinician raters at baseline and at two-year follow-up, and blood samples were obtained at both visits. LTL was assayed under identical methods using quantitative polymerase chain reaction (qPCR). The effect of an MDD diagnosis at baseline on change in LTL over two years was examined via hierarchical mixed models, which included potential confounders. Results: Individuals with MDD at baseline had greater LTL shortening over two years than individuals without MDD (p = 0.03), even after controlling for differences in age, sex, and body mass index (BMI). In the sub-sample of individuals with MDD diagnoses at baseline, no significant associations between LTL change and symptom severity or duration were found. Conclusion: A baseline diagnosis of MDD prospectively predicted LTL shortening over two years. Our results provide further support for MDD as a disease associated with accelerated aging in a well-characterized sample using validated, clinician-rated measures.

【 授权许可】

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