COVID-19 and psychosis risk: Real or delusional concern?

NEUROSCIENCE LETTERS

卷:741

Review

Watson, Cameron J.¹  Thomas, Rhys H.^3,4  Solomon, Tom^5,6,7  Michael, Benedict Daniel^5,6,7  Nicholson, Timothy R.²  Pollak, Thomas A.² 

[1] Queen Mary Univ London, Wolfson Inst Prevent Med, Prevent Neurol Unit, London, England

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[3] Univ Newcastle, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England

[4] Royal Victoria Infirm, Newcastle Upon Tyne, Tyne & Wear, England

[5] Walton Ctr NHS Fdn Trust, Dept Neurol, Liverpool, Merseyside, England

[6] Univ Liverpool, Natl Inst Hlth Res Hlth Protect Res Unit Emerging, Liverpool, Merseyside, England

[7] Univ Liverpool, Inst Infect Vet & Zool Sci, Clin Infect Microbiol & Immunol, Liverpool, Merseyside, England

关键词: Psychosis;    COVID-19;    SARS-CoV-2;    Neuropsychiatry;    Neurology;    Psychiatry;    Schizophrenia;    Encephalitis;   

DOI  :  10.1016/j.neulet.2020.135491

来源: Elsevier

【 摘 要 】

Historical epidemiological perspectives from past pandemics and recent neurobiological evidence link infections and psychoses, leading to concerns that COVID-19 will present a significant risk for the development of psychosis. But are these concerns justified, or mere sensationalism? In this article we review the historical associations between viral infection and the immune system more broadly in the development of psychosis, before critically evaluating the current evidence pertaining to SARS-CoV-2 and risk of psychosis as an acute or post-infectious manifestation of COVID-19. We review the 42 cases of psychosis reported in infected patients to date, and discuss the potential implications of in utero infection on subsequent neurodevelopment and psychiatric risk. Finally, in the context of the wider neurological and psychiatric manifestations of COVID-19 and our current understanding of the aetiology of psychotic disorders, we evaluate possible neurobiological and psychosocial mechanisms as well as the numerous challenges in ascribing a causal pathogenic role to the infection.

【 授权许可】

Free