Chronic administration of antipsychotics impede behavioral recovery after experimental traumatic brain injury

NEUROSCIENCE LETTERS

卷:448

Article

Kline, Anthony E.^1,3,4,5  Hoffman, Ann N.³  Cheng, Jeffrey P.³  Zafonte, Ross D.^6,7,8  Massucci, Jaime L.² 

[1] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA 15213 USA

[2] Christiana Care Hlth Syst, Emergency Med, Newark, DE 19718 USA

[3] Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Ctr Neurosci, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Ctr Neural Basic Cognit, Pittsburgh, PA 15213 USA

[6] Harvard Univ, Sch Med, Boston, MA 02114 USA

[7] Spaulding Rehabil Hosp, Boston, MA 02114 USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

关键词: Antipsychotics;    Beam-walk;    Controlled cortical impact;    Functional recovery;    Haloperidol;    Learning and memory;    Morris water maze;    Neurobehavior;    Risperidone;    Traumatic brain injury;   

DOI  :  10.1016/j.neulet.2008.10.076

来源: Elsevier

【 摘 要 】

Antipsychotics are often administered to traumatic brain injured (TBI) patients as a means of controlling agitation, albeit the rehabilitative consequences of this intervention are not well known. Hence. the goal of this study was to evaluate the effects of risperidone (RISP) and haloperidol (HAL) on behavioral outcome after experimental TBI. Anesthetized rats received either a cortical impact or sham injury and then were randomly assigned to five TBI (RISP 0.045 mg/kg, RISP 0.45 mg/kg, RISP 4.5 mg/kg, HAL 0.5 mg/kg and VEHicle 1 ml/kg) and three Sham (RISP 4.5 mg/kg, HAL 0.5 mg/kg and VEH 1 mL/kg) groups. Treatments began 24 h after surgery and were provided once daily for 19 days. Behavior was assessed with established motor (beam-balance/walk) and cognitive (spatial learning/memory in a water maze) tasks on post-operative days 1-5 and 14-19, respectively. RISP and HAL delayed motor recovery, impaired the acquisition of spatial learning, and slowed swim speed relative to VEH in both TBI and sham groups. These data indicate that chronic administration of RISP and HAL impede behavioral recovery after TBI and impair performance in uninjured controls. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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